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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACO1
All Species:
35.45
Human Site:
S138
Identified Species:
55.71
UniProt:
P21399
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P21399
NP_002188.1
889
98399
S138
D
F
N
R
R
A
D
S
L
Q
K
N
Q
D
L
Chimpanzee
Pan troglodytes
XP_001155934
889
98362
S138
D
F
N
R
R
A
D
S
L
Q
K
N
Q
D
L
Rhesus Macaque
Macaca mulatta
XP_001103675
889
98487
S138
D
F
N
R
R
A
D
S
L
Q
K
N
Q
D
L
Dog
Lupus familis
XP_538698
889
98299
S138
D
F
N
R
R
T
D
S
L
Q
K
N
Q
D
L
Cat
Felis silvestris
Mouse
Mus musculus
P28271
889
98160
S138
D
F
N
R
R
A
D
S
L
Q
K
N
Q
D
L
Rat
Rattus norvegicus
Q63270
889
98109
S138
H
F
N
R
R
A
D
S
L
Q
K
N
Q
D
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509375
889
98624
S138
D
F
N
R
R
V
D
S
L
Q
K
N
Q
D
L
Chicken
Gallus gallus
Q90875
889
98055
S138
D
F
N
R
R
S
D
S
L
Q
K
N
Q
D
L
Frog
Xenopus laevis
Q6NTP2
955
104418
A137
D
F
T
K
C
I
A
A
Q
N
V
S
G
L
P
Zebra Danio
Brachydanio rerio
NP_001030155
890
98920
S138
D
F
N
R
K
S
D
S
L
Q
K
N
Q
D
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524303
899
98560
A142
D
F
A
R
A
P
D
A
L
A
K
N
Q
S
L
Honey Bee
Apis mellifera
XP_392993
890
98796
A140
D
F
F
R
T
K
D
A
F
K
K
N
E
E
M
Nematode Worm
Caenorhab. elegans
Q23500
887
96642
A136
D
H
Y
G
N
L
E
A
L
A
K
N
Q
S
I
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SIB9
990
108183
A234
D
V
A
R
S
E
N
A
V
Q
A
N
M
E
L
Baker's Yeast
Sacchar. cerevisiae
P19414
778
85350
G81
H
G
Q
D
I
Q
R
G
V
S
Y
L
K
L
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
98.9
93.2
N.A.
93.4
92.9
N.A.
90.4
87.5
55.7
82.2
N.A.
67.9
69.4
62.9
N.A.
Protein Similarity:
100
100
99.5
96.9
N.A.
97.7
97.7
N.A.
95.1
93.8
72.2
92
N.A.
82.1
82.5
77.1
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
100
93.3
N.A.
93.3
93.3
13.3
86.6
N.A.
60
40
33.3
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
100
93.3
N.A.
93.3
100
33.3
100
N.A.
66.6
73.3
53.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
55.6
26.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
69.6
43.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
33.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
60
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
14
0
7
34
7
34
0
14
7
0
0
0
0
% A
% Cys:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
87
0
0
7
0
0
74
0
0
0
0
0
0
60
0
% D
% Glu:
0
0
0
0
0
7
7
0
0
0
0
0
7
14
0
% E
% Phe:
0
80
7
0
0
0
0
0
7
0
0
0
0
0
0
% F
% Gly:
0
7
0
7
0
0
0
7
0
0
0
0
7
0
0
% G
% His:
14
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
7
7
0
0
0
0
0
0
0
0
7
% I
% Lys:
0
0
0
7
7
7
0
0
0
7
80
0
7
0
0
% K
% Leu:
0
0
0
0
0
7
0
0
74
0
0
7
0
14
74
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
7
% M
% Asn:
0
0
60
0
7
0
7
0
0
7
0
87
0
0
0
% N
% Pro:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
7
% P
% Gln:
0
0
7
0
0
7
0
0
7
67
0
0
74
0
0
% Q
% Arg:
0
0
0
80
54
0
7
0
0
0
0
0
0
0
7
% R
% Ser:
0
0
0
0
7
14
0
60
0
7
0
7
0
14
0
% S
% Thr:
0
0
7
0
7
7
0
0
0
0
0
0
0
0
0
% T
% Val:
0
7
0
0
0
7
0
0
14
0
7
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
0
0
0
0
0
0
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _